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The role of E2 in regulating the effect of 5-HT. E2 increases the mRNA expression of TPH through exciting ERβ. ERβ regulates 5-HT through BDNF–5-HT2a pathway. E2 increases the reactivity of 5-HT to SSRI drugs. The effect of E2 on 5-HT depends on whether the model is established or not and the administration period.
