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The interaction between GR and FKBP5. Glucocorticoid receptor (GR) can form a chaperone complex with FKBP5 and heat shock protein 90 as an intracellular receptor to prevent GR from being transported to the nucleus. After binding glucocorticoid (GC), GR dissociates and binds to the fkkbp5 enhancer-binding site, produces more FKBP5, conducting a negative feedback loop.
