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. 2022 Jun 1;21:121. doi: 10.1186/s12943-022-01599-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CircSTX6 facilitates the tumorigenesis and metastasis of PDAC cells in vivo. a Representative picture of subcutaneous xenograft tumors (n = 6 for each group). b-c Curves of tumor volumes and weights show negative effects of circSTX6 knockdown on the formation of subcutaneous xenograft tumors. d HE and Ki-67 IHC staining of xenograft tumors. Original magnification 400×. Scale bar = 50 μm. H-scores of the Ki67 staining. e Representative images and analysis of luminescence intensity in tail vein tumor metastasis mouse models (n = 6 for each group). f Representative images and HE staining of metastatic nodules in the lungs and livers of mice. Original magnification 100×. Scale bar = 200 μm. g The numbers of lung and liver metastatic nodules were measured. (Values are expressed as the means ± SDs; *P < 0.05, **P < 0.01 and ***P < 0.001)