Table 2.

Univariate and multivariate analyses of overall survival in PDAC patients (n = 97)

Variables	Univariable analysis				Multivariable analysis
	HR	95%CI	P value		HR	95%CI	P value
Gender (Female vs. Male)	0.838	0.470–1.494	0.549
Age (≥ 60y vs. < 60y)	1.071	0.562–2.041	0.834
Location (Body + tail vs. Head)	0.635	0.344–1.171	0.146
Tumor_differentiation (G3 vs. G1 + G2)	1.015	0.578–1.781	0.96
TNM stage (III + IV vs. I + II)	1.479	0.846–2.588	0.17
T stage (T3 + T4 vs. T1 + T2)	1.882	1.086–3.262	0.024*		1.621	0.870–3.021	0.128
N stage (N1 + N2 vs. N0)	1.022	0.593–1.761	0.939
Nerve invasion (Yes vs. No)	2.038	0.634–6.549	0.232
Major vascular invasion (Yes vs. No)	1.907	0.957–3.801	0.067		1.363	0.633–2.936	0.428
Serum CA19_9 (≥ 37U/ml vs. < 37U/ml)	1.442	0.615–3.380	0.399
CircSTX6 expression (High vs. Low)	2.025	1.162–3.528	0.013*		3.013	1.655–5.486	< 0.001***
miR-449b-5p expression (High vs. Low)	0.47	0.269–0.820	0.008**		0.426	0.232–0.780	0.006**

HR hazard ratio, CI confidence interval, TNM tumor node metastasis. Cox regression analysis, *p < 0.05, **p < 0.01, ***p < 0.001