Table 1.
Multivariate Cox regression analysis of the impact of factors on survival in patients with lower limb onset ALS.
| Variable | HR | 95% CI | p |
|---|---|---|---|
| Gender | |||
| Women | 1.000 | ||
| Men | 1.191 | 0.881–1.609 | 0.256 |
| Onset age (years) | 1.034 | 1.019–1.049 | <0.001 |
| Diagnostic delay (months) | 0.960 | 0.939–0.982 | <0.001 |
| Duration (months) | 0.895 | 0.866–0.926 | <0.001 |
| ALSFRS-R | 0.957 | 0.929–0.985 | 0.003 |
| Use of riluzole | |||
| No | 1.000 | ||
| Yes | 0.713 | 0.519–0.980 | 0.037 |
| Use of NIV | |||
| No | 1.000 | ||
| Yes | 0.553 | 0.340–0.900 | 0.017 |
| Use of PEG | |||
| No | 1.000 | ||
| Yes | 2.933 | 0.381–22.608 | 0.302 |
ALS, amyotrophic lateral sclerosis; HR, hazard ratio; CI, confidence interval; Duration, duration from lower limb onset to second significant region involvement; ALSFRS-R, ALS Functional Rating Scale-Revised; NIV, non-invasive ventilation; PEG, percutaneous endoscopic gastrostomy.