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. 2022 May 31;22:205. doi: 10.1186/s12935-022-02623-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Inhibition of MST1/2 rescues the effect of MT2A on CRC cells. A XUM-MP-1 is a specific inhibitor of MST1/2. 2 μM XUM-MP-1 was added and cultured for 6 h. The results showed that both p-MST1 and p-YAP1 were significantly inhibited in HCT8 and HCT116 cells. B, C Colony formation assays showed that XUM-MP-1 promoted colony formation in HCT8 and HCT116 cells as well as rescued the inhibitory effect of MT2A overexpression. D The CCK-8 assay showed that XUM-MP-1 significantly increased the cell proliferation rate of MT2A-overexpressing cells. E IHC staining of MT2A showed that the MT2A overexpression group consistently overexpressed MT2A in subcutaneous tumors. P-MST1 and p-YAP1 were upregulated in the MT2A overexpression group compared to the control group. F Consistent with subcutaneous tumors, IHC staining of liver metastasis tumors showed that MT2A overexpression increased the expression of MT2A, p-MST1 and p-YAP1. Scale bar = 100 μm, OE, overexpression. *p < 0.05, **p < 0.01