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. 2022 Jun 1;15:66. doi: 10.1186/s13048-022-00979-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Over-expression of circRHOBTB3 reverses miR-23a-3p-fostered malignancy in OC cells. A In the CCK8 assay, proliferation circRHOBTB3 competively reduced the proliferation of SKOV3 and OVCAR8 cells that miR-23a-3p increased (one-way ANOVA). B CircRHOBTB3 competitively stagnated cells in the G1 period that could be released by miR-23a-3p (one-way ANOVA). C Transwell matrigel invasion assay demonstrated that miR-23a-3p fostered the invasion ability of SKOV3 and OVCAR8 cells; however, when co-transfected with circRHOBTB3, this effect was significantly attenuated (one-way ANOVA). D Apoptosis assay was performed to show whether circRHOBTB3 could rescue miR-23a-3p’s inhibition of apoptosis (one-way ANOVA)