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. 2022 May 31;22:1082. doi: 10.1186/s12889-022-13490-5

Table 5.

Moderation of age, sex, and fitness on the association between cognitive functions and movement behavior changes

Δ Executive Function Δ Episodic Memory Δ Processing Speed Δ Global Cognition
Moderation of age Estimates (95%CI) Estimates (95%CI) Estimates (95%CI) Estimates (95%CI)
Δ ilr1 Time in bed 0.26 * (0.03–0.49) 0.19 (− 0.17–0.55) 0.13 (− 0.08–0.34) 0.26 * (0.09–0.42)
Δ ilr1 Sedentary behavior 0.08 (− 0.17–0.34) 0.35 (− 0.06–0.77) 0.04 (− 0.20–0.29) 0.13 (− 0.06–0.31)
Δ ilr1 Light physical activity 0.09 (− 0.13–0.31) 0.11 (− 0.25–0.46) 0.04 (− 0.17–0.26) 0.09 (− 0.07–0.25)
Δ ilr1 Moderate physical activity −0.24 (− 0.49–0.00) 0.08 (− 0.34–0.50) − 0.19 (− 0.43–0.05) − 0.14 (− 0.32–0.04)
Δ ilr1 Vigorous physical activity − 0.03 (− 0.12–0.07) −0.10 (− 0.26–0.05) −0.02 (− 0.11–0.07) −0.05 (− 0.11–0.02)
Moderation of sex
 Δ ilr1 Time in bed 3.61 (− 0.79–8.02) −3.97 (− 11.50–3.55) −3.57 (− 7.94–0.81) 0.24 (− 3.00–3.49)
 Δ ilr1 Sedentary behavior 3.63 (− 0.56–7.82) −3.01 (− 10.16–4.15) − 4.69 * (− 8.80 – − 0.58) −0.06 (− 3.15–3.04)
 Δ ilr1 Light physical activity 2.42 (− 1.63–6.47) − 2.05 (− 8.91–4.80) − 1.26 (− 5.30–2.78) 0.49 (− 2.47–3.46)
 Δ ilr1 Moderate physical activity − 0.90 (− 4.50–2.70) 2.11 (− 4.03–8.25) 1.03 (− 2.57–4.64) 0.51 (− 2.13–3.14)
 Δ ilr1 Vigorous physical activity −1.17 (− 2.70–0.37) 0.77 (− 1.85–3.40) 1.11 (− 0.41–2.63) −0.23 (− 1.36–0.89)
Moderation of Fitness
 Δ ilr1 Time in bed −0.04 (− 0.29–0.21) −0.36 (− 0.76–0.04) −0.09 (− 0.32–0.15) −0.14 (− 0.32–0.04)
 Δ ilr1 Sedentary behavior 0.14 (− 0.10–0.38) − 0.39 (− 0.79–0.01) 0.08 (− 0.16–0.31) −0.00 (− 0.18–0.17)
 Δ ilr1 Light physical activity 0.06 (− 0.14–0.27) − 0.03 (− 0.37–0.32) 0.00 (− 0.20–0.21) 0.02 (− 0.13–0.17)
 Δ ilr1 Moderate physical activity 0.20 (−0.06–0.45) 0.06 (− 0.38–0.50) 0.19 (−0.07–0.44) 0.19 * (0.00–0.37)
 Δ ilr1 Vigorous physical activity −0.05 (− 0.14–0.03) 0.09 (− 0.06–0.23) −0.02 (− 0.11–0.07) −0.01 (− 0.08–0.06)
 No. of observations 134 138 138
* p < 0.05

Linear mixed model estimates of the three-way interactions between changes in movement behavior ilr1 (i.e., Time in bed, Sedentary behavior, and Light, Moderate, and Vigorous physical activity), changes in cognitive domain (i.e., Executive function, Episodic memory, and Processing speed) and the moderator (i.e., age, sex, or fitness) with 95% confidence interval. Significant moderations are marked with *