TABLE 3.

Selected signaling pathways and transcription factors involved in chronic kidney injury in cancer patients.

Pathways/transcription factor	Animal model/cell analyzed	Indications	Results	References
VEGF	Adult mice with renal podocytes deleted with VEGF	Glomerular injury in patients treated with bevacizumab might be due to direct targeting of VEGF by antiangiogenic therapy	Thrombotic glomerular injury	Eremina et al. (2008)
NLRP3/Caspase-1/GSDMD	Vitamin D receptor knockout mice	NF-κB could mediate NLRP3/Caspase-1/GSDMD pathway of pyroptosis pathway to increase cisplatin-induced AKI.	Apoptosis and necrosis of the renal tubular epithelial cells	Jiang et al. (2021)
	Vitamin D receptor knockout human tubular epithelial cells
JAK2/STAT1	Human proximal tubular epithelial cells	Monoclonal FLCs produce pro-inflammatory and pro-fibrotic events in proximal tubules leading to CKD through activation of the JAK2/STAT1 pathway	Renal tubular interstitial disease complicated by proximal tubular injury	Ying et al. (2019)
STAT1/HMGB1/TLR	Human kidney proximal tubular epithelial cells	The activation of TLR was involved in FLC-mediated renal inflammation	Renal tubular interstitial disease	Upadhyay et al. (2020)
	Stat1 knockout mice