Table 1.
Clinical characteristics of participants in the first 2 years after PD initiation
| Baseline | 1st year | 2nd year | |
|---|---|---|---|
| Age | 54.3 ± 16.8 | / | / |
| Male, n(%) | 130(60.2%) | / | / |
| CAPD,n(%) | 202(93.5%) | / | / |
| BMI (kg/m2) | 22.4 ± 3.3 | 23.3 ± 3.6* | 23.6 ± 3.8 |
| SBP (mmHg) | 140(130,155) | 130(117,145) | 131(120,141) |
| DBP (mmHg) | 80(73,90) | 80(70,90) | 80(72,90) |
| MAP | 100.7(93.3,110.0) | 96.7(89.7,106.7)* | 98.0(90.0,106.7)* |
| LVDd (cm) | 5.0(4.6,5.4) | 4.9(4.5,5.3)* | 4.9(4.4, 5.2)* |
| PWT (cm) | 1.1(0.9,1.2) | 1.0(0.9,1.1)* | 1.0(0.9,1.2)* |
| IVS (cm) | 1.1(1.0,1.3) | 1.1(1.0,1.3) | 1.1(1.0,1.3) |
| LVMI (g/m2) | 128.9(107.7, 154.9) | 115.9(98.1,136.6)* | 116.6(93.3,139.6)* |
| LVEF (%) | 66.0(62.0,71.0) | 67.0(64.0,71.0) | 67.0(63.0,72.0) |
| E/A ratio | 0.79(0.63,1.00) | 0.73(0.61,0.90) | 0.71(0.59,0.87) |
| Dialysis-related variables | |||
| nPCR (g/kg/24 h) | 0.91 ± 0.19 | 0.95 ± 0.20 | 0.92 ± 0.22 |
| Urinary output(L/24 h) | 1.10(0.63,1,50) | 0.80(0.40,1.33)* | 0.55(0.08,1.10)*# |
| Total Ccr (L/week) | 78.4(62.4,96.7) | 64.9(52.5,80.2)* | 54.5(47.5,72.1)*# |
| Residual renal Ccr (L/week) | 43.0(27.4,64.2) | 30.7(13.6,46.7)* | 17.1(0.83,38.2)* |
| Total Kt/V | 2.04(1.76,2.42) | 1.86(1.62,2.14) | 1.79(1.58,2.08)* |
| Residual renal Kt/V | 0.84(0.50,1.21) | 0.63(0.24,0.93)* | 0.33(0.01, 0.72)*# |
| Volume of dialysate (per 1000 mL/24 h) | 5.98(5.51,6.37) | 6.21(5.75,7.89)* | 6.60(6.00,8.70)*# |
| Proportion of 1.5%-glucose dialysate(%) | 100(100,100) | 70.8(66.7,100) | 100(66.7,100) |
| Biochemical parameters | |||
| Hemoglobin (g/L) | 86.7 ± 19.0 | 106.1 ± 16.7* | 107.0 ± 16.9* |
| Ferritin (ng/ml) | 192.1(86.4,370.5) | 212.6(140.7,344.5) | 216.9(131.3,305.5) |
| Serum iron (umol/L) | 10.3(7.7,14.1) | 12.6(9.9,17.4)* | 12.8(9.9,16.6)* |
| Iron saturation (%) | 27.0(20.0,37.0) | 33.0(25.0, 43.0)* | 32.0(24.0,41.0)* |
| Albumin (g/L) | 35.3 ± 5.1 | 35.9 ± 5.0 | 36.4 ± 4.8* |
| Calcium (mmol/L) | 2.05(1.89, 2.19) | 2.18(2.05, 2.34)* | 2.24(2.09,2.37)* |
| Phosphate (mmol/L) | 1.62(1.30,1.97) | 1.49(1.25,1.72)* | 1.49(1.24,1.79)* |
| iPTH (pg/ml) | 270.5(158.4,440.0) | 261.2(156.5,408.6) | 255.5(164.0,389.5) |
| CHO (mmol/L) | 4.13(3.54,5.11) | 4.24(3.65,4.93) | 4.18(3.61,5.02) |
| TG (mmol/L) | 1.39(1.05,1.98) | 1.68(1.15,2.47)* | 1.72(1.15,2.56)* |
| LDL (mmol/L) | 2.33(1.87,2.93) | 2.17(1.74,2.66)* | 2.19(1.72,2.71)* |
| HDL (mmol/L) | 0.95(0.81,1.18) | 0.91(0.77,1.13) | 0.90(0.75,1.12)* |
| ApoA1 (g/L) | 0.97(0.84,1.10) | 1.00(0.88,1.15)* | 0.99(0.87,1.17) |
| ApoB (g/L) | 0.65(0.55,0.81) | 0.66(0.56,0.78) | 0.66(0.57.0.77) |
| NT-proBNP (per 1000 pg/ml) | 1.81(0.83,6.45) | 1.31(0.57,3.08)* | 1.89(0.70,6.41)# |
| hsCRP (mg/L) | 2.11(0.47,4.46) | 0.86(0.33,2.79)* | 0.85(0.41,2.67)* |
| FIB (g/L) | 3.48(2.95,4.32) | 3.80(3.39,4.40)* | 3.82(3.32,4.45)* |
CAPD continuous ambulatory peritoneal dialysis, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, nPCR normalized protein catabolic rate, Ccr creatinine clearance, Kt/V urea clearance, CHO cholesterol, TG triglyceride, LDL low-density lipoprotein, HDL high-density lipoprotein, NT-proBNP N-terminal pro brain natriuretic peptide, hsCRP high-sensitivity C-reactive protein, FIB fibrinogen
*p < 0.05 vs. baseline; #p < 0.05 vs. 1st year