Table 2.

PLSCR1 interactions in the nucleus

Cellular processes affected	Protein	Disease	Study models	Methods	Effects of PLSCR1 interaction	References
Nuclear import	Importin-α	N.A	Murine SVT2 fibroblasts	- Fluorescence Anisotropy Assay - Crystallographic Analysis	Favors PLSCR1 entrance into the nucleus	[16]
- Cell migration - Invasion - Stemness	STAT3	BLBC	- MDA -MB231 - SUM159 - MCF7 - HCC1937 - T47D - MDA -MB468	- MS - CO-IP	Activates STAT1 transcription thus inducing cancer stem cell properties	[81]
Cell differentiation	IP3R1 promoter	AML	Primary leukemia cells	EMSA	Induces cell cycle arrest and cell differentiation promoted by Wogonoside	[43, 77]
Cell signaling	TOPO IIα TOPO IIβ	N.A	HeLa	- Yeast two hybrid screening - GST-pull-down assay - CO-IP	Increases DNA decatenating ability of Topo IIα	[15]
Cell proliferation	ANG MK	N.A Hepatic carcinoma	HeLa HepG2	- Yeast two hybrid screening - GST-pull-down assay - CO-IP - FRET	Positively regulates rRNA transcription	[83]
				- GST-pull-down assay - CO-IP	Promotes cell proliferation and migration	[80]

N.A. Not applicable, PLSCR1 Phospholipid scramblase 1, BLBC Basal-like breast cancer, STAT3 Signal Transducer And Activator Of Transcription 3, STAT1 Signal Transducer And Activator Of Transcription 1, MS Mass spectrometry, CO-IP co-immunoprecipitation, IP3R1 1,4,5-trisphosphate receptor 1, AML acute myeloid leukemia, EMSA Electrophoretic mobility shift assay, TOPO II DNA topoisomerase II, ANG Angiogenin, FRET fluorescent resonance energy transfer, MK Midkine