Table 2.

Diagnoses that appear in at least 25 directional diagnosis pairs (D1 → D2)

ICD-10	Description	Number of trajectories per diagnosis			Number of distinct patients per trajectory with diagnosis
		Total	D1	D2	Total	D1	D2
I10	Hypertension	129	126	6	249,797	249,652	44,326
I25	Chronic ischemic heart disease	104	93	11	355,100	354,669	61,979
E11	Non-insulin-dependent diabetes	90	89	1	101,507	101,493	2,525
I20	Angina pectoris	71	46	25	316,688	293,978	280,966
I48	Atrial fibrillation	56	42	10	146,221	139,275	102,242
E10	Insulin-dependent diabetes	45	44	1	43,243	43,140	34,656
I50	Heart failure	52	23	29	167,838	149,446	159,595
E78	Dyslipidemia	52	47	5	155,389	155,324	28,788
E66	Obesity	42	42	0	44,324	44,324	0
M62	Other disorders of muscle	41	41	0	38,598	38,598	0
I21	Acute myocardial infarction	40	14	26	235,633	187,056	200,793
E86	Volume depletion	39	1	38	58,469	47,417	56,836
H25	Senile cataract	37	13	24	124,799	104,124	117,541
I46	Cardiac arrest	30	1	31	20,263	16,583	20,263
N92	Excessive, frequent, and irregular menstruation	29	28	1	14,503	14,503	479
M81	Osteoporosis without pathological fracture	29	7	22	37,727	28,832	37,727
K57	Diverticular disease of intestine	28	3	25	46,705	27,008	46,189
J96	Respiratory failure, not elsewhere classified	28	1	27	40,819	32,119	40,457
J44	Other chronic obstructive pulmonary disease	28	25	3	89,885	88,625	16,051
D64	Other anemias	27	1	26	61,109	46,546	60,239
N30	Cystitis	26	13	13	78,603	70,081	70,428
J42	Unspecified chronic bronchitis	25	25	0	22,546	22,546	0
I69	Sequelae of cerebrovascular disease	25	15	10	56,998	54,771	54,410