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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Circulation. 2021 Nov 24;145(5):357–370. doi: 10.1161/CIRCULATIONAHA.121.055117

Figure 2. Summary of protein quantitative trait loci.

Figure 2.

a, Significance level of cis associations according to distance from transcription start site for the cognate gene. b, Number of loci associated with each protein. c, Number of proteins associated with each locus. d,e, Proportion of pQTLs within and between genes, and by GENCODE comprehensive category for each pQTL, darker bars represent novel variant-protein associations. f, Absolute effect size versus minor allele frequency. Small circles indicate known sentinel variant-protein associations, large circles are novel associations. SNPs: single nucleotide polymorphisms. “Exact” indicates that the variant-protein association has been previously identified. “Novel” indicates that the variant-protein associations is novel.