Table 4:

Association of metabolites with incident heart failure in the Framingham Heart Study

	Model 1*				Model 2†
Metabolite	Hazard Ratio	95% CI	P value	Q value	Hazard Ratio	95% CI	P value	Q value
Choline	1.24	1.08−1.44	0.003	0.01	1.16	0.99−1.37	0.08	0.24
2-aminoadipic acid	1.2	1.03−1.41	0.02	0.03	1.03	0.86−1.24	0.73	0.74
Uridine	0.91	0.79−1.01	0.23	0.2	0.94	0.80−1.11	0.49	0.73

^*Model 1: Adjusted for age, sex and batch

^†Model 2: Model 1+ body mass index, eGFR, total cholesterol, high density lipoprotein, coronary heart disease, diabetes, hypertension, systolic blood pressure and smoking status.