Table 5:

Competing risk model for differential association of metabolites with HFpEF vs. HFrEF

	HFrEF (n=77)		HFpEF (n=87)		Difference*
Metabolites	Hazard ratio	P value	Hazard ratio	P value	P value
HFpEF
Orotic acid	0.86 (0.76−0.98)	0.25	1.37 (1.28−1.46)	4.10E-06	4.4E-03
C18.0.LPE_A	0.88 (0.78−0.98)	0.28	1.35 (1.21−1.49)	4.8E-03	7.8E-03
ATP	0.924(0.83−1.03)	0.46	1.46 (1.29−1.65)	2.9E-03	9.1E-03
C18.1.LPC.plasmalogen_minor	0.83 (0.74−0.93)	0.098	1.32 (1.18−1.49)	0.018	9.6E-03
C16.1.LPC.plasmalogen	0.808 (0.71−0.90)	0.069	1.28 (1.14−1.44)	0.033	9.9E-03
C18.1.LPC	0.873 (0.77−0.98)	0.24	1.33 (1.18−1.48)	0.014	0.012
N.methylproline	1.05 (0.93−1.17)	0.68	0.69 (0.616−0.773)	0.001	0.020
C18.1.LPC.plasmalogen	0.885 (0.80−0.97)	0.22	1.29 (1.15−1.46)	0.033	0.021
C16.0.LPE	0.876 (0.77−0.98)	0.27	1.3 (1.17−1.44)	0.011	0.024
HFrEF
C22.5.LPC	0.768 (0.685−0.861)	0.02	1.22 (1.06−1.39)	0.15	0.0188
1.methyladenosine	1.59 (1.38−1.84)	0.001	0.984 (0.863−1.12)	0.9	0.0242
C22.6.LPC	0.759 (0.675−0.853)	0.018	1.09 (0.972−1.23)	0.45	0.0358

Model adjusted for age, sex, batch, body mass index, hypertension, systolic blood pressure, diabetes, eGFR, total cholesterol, high density lipoprotein, smoking status, history of coronary heart disease

^*P value for differential association in risk model based on bootstrap sampling

HFpEF: heart failure with preserved ejection fraction; HFrEF: heart failure with preserved ejection fraction