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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Biomed Mater Res B Appl Biomater. 2016 Jun 28;105(7):1986–2000. doi: 10.1002/jbm.b.33736

FIGURE 3.

FIGURE 3.

HA-HP hydrogel supports long-term release of (A) FGF and (B) VEGF secreted by encapsulated AFS cells. Red line—HA-HP supports significantly greater daily VEGF release than HA gels (p < 0.05). Blue line—time period during which zero FGF/VEGF is released from the HA gels. Release kinetic models (first order release, Hixson–Crowell release, Higuchi release, and Korsmeyer–Peppas release) were fit to the data characterizing the mechanism of release. High R2 values of the Higuchi and Korsmeyer–Peppas models indicate that the release is mediated by diffusion through a polymer matrix, as expected. Dotted box—regression line fit to Extracel-HP curve. Dashed box—regression line fit to the fibrin–collagen curve. The x-coefficients of the regression lines indicate Fickian versus non-Fickian diffusion.