TABLE 1.
Serotonin (5‐HT) receptor modulation and their preclinical/clinical potential
| Improvement of (neurological) diseases and/or health features by | |||||
|---|---|---|---|---|---|
| 5‐HT receptor | Stimulation | Inhibition | Main reference(s) | ||
| Preclinical | Clinical | Preclinical | Clinical | ||
| 1A | Aggression, anxiety, craving, depression, epilepsy, impulsivity, sleep | TLE (?), anxiety, depression | Absence epilepsy, cognition | Depression | 43, 172 |
| 1B | Aggression, locomotor activity, sleep | — | — | — | 58, 172 |
| 1D | Depression, epilepsy | Migraine | — | — | 59, 172 |
| 1E | — | — | — | — | 64 |
| 1F | Migraine | — | — | — | 68 |
| 2A | Appetite, the absence epilepsy thermoregulation, sleep, SUDEP | Cognition | — | Psychosis, sleep | 70 |
| 2B | — | — | Cardiotoxicity, schizophrenia, drug addiction | Pulmonary hypertension | 94 |
| 2C | Appetite, (absence) epilepsy | Appetite, epilepsy | — | — | 83 |
| 3 | Epilepsy, SUDEP | — | Anxiety, cognition, depression, migraine, pain | Nausea, vomiting, psychosis | 173 |
| 4 | Cognition, depression epilepsy, SUDEP | Constipation, IBS, reflux | Anxiety, epilepsy | 117 | |
| 5 | Cognition | — | — | — | 120 |
| 6 | Depression | — | Cognition, depression, epilepsy | TLE (?) | 121 |
| 7 | Behavior, cognition, epilepsy, mood | — | Cognition, depression, epilepsy | — | 128 |
(?) indicates uncertain effects of pharmacological modulation of this receptor subtype. See text for all the references of these (pre)clinical studies.
Abbreviations: IBS, irritable bowel syndrome; OCD, obsessive‐compulsive behavior; sudden unexplained death in epilepsy patients (SUDEP); TLE, temporal lobe epilepsy.