Figure 6.

A model for 3D organization of DNA loci within RNA-chromatin compartments. Nuclear bodies can act as hubs for DNA interactions. One model for establishing such DNA interactions involves the coalescence of proteins at a nuclear body. Specifically, this may occur by RNA transcription occurring at multiple DNA loci, followed by recruitment of proteins to these sites, growth and coalescence of droplets, and merging of droplets into a single nuclear body. This series of events would create a hub of DNA interactions around a large nuclear body.