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Mycobacterium tuberculosis–infected BALB/c mice (n = 2 per time point) were treated 5 times per week for 4 weeks with bedaquiline (25 mg/kg), pretomanid (100 mg/kg), moxifloxacin (100 mg/kg), and pyrazinamide (150 mg/kg). Bedaquiline and its N-desmethyl bedaquiline metabolite (M2) (A), pretomanid (B), moxifloxacin (C), and pyrazinamide (D) serum concentration-time profiles are plotted as means with ranges (error bars) at various time points after the last drug administration.
