Figure 3.

Mycobacterial load in lung (A, B) and spleen (C, D) expressed as medians with ranges (error bars) of colony-forming units (CFUs) at 12 weeks after different treatment durations. Mice were treated with bedaquiline and pretomanid combined with either moxifloxacin and pyrazinamide (BPaMZ) (A, C) or linezolid (BPaL) (B, D). Numbers above bars indicate the number of mice with cure relative to the total number examined. Dashed horizontal lines indicate the upper limits of detection (in CFUs). *CFU counting of 1 plate could not be performed owing to contamination. †One mouse reached humane end points and was euthanized before the planned date. Heart and lungs from this mouse were cultured, and no CFUs were recovered on the plates.