Table 1.
Pharmacokinetic Analysis Serum Values by Treatment Regimen (n = 2 per Time Point)
| Regimen | Compound (mg/kg) | Cmax, Range, mg/L | AUC0–24h, Mean (SEM), mg ⋅ h/L |
|---|---|---|---|
| BPaMZ | Bedaquiline (25) | 0.81–1.20 | 15.52 (1.22) |
| N-desmethyl bedaquiline | 4.55–4.87 | 95.78 (2.34) | |
| Pretomanid (100) | 6.89–7.03 | 104.20 (2.44) | |
| Moxifloxacin (100) | 4.78–4.96 | 15.70 (1.67) | |
| Pyrazinamide (150) | 89.90-81.60 | 186.80 (9.41) | |
| BPaL | Bedaquiline (25) | 1.20–1.26 | 15.32 (2.75) |
| N-desmethyl bedaquiline | 4.07–5.11 | 91.61 (9.54) | |
| Pretomanid (100) | 7.70–9.50 | 99.13 (15.14) | |
| Linezolid (100) | 28.70–68.90 | 240.00 (28.84) |
Abbreviations: AUC0–24h, area under the concentration-time curve over 24 hours; BPaL, bedaquiline and pretomanid combined with linezolid; BPaMZ, bedaquiline and pretomanid combined with moxifloxacin and pyrazinamide; Cmax, maximum serum concentration; SEM, standard error of the mean.