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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Compr Physiol. 2021 Dec 29;12(1):2877–2947. doi: 10.1002/cphy.c210020

Figure 17. The loss of muscle spindle feedback in mice impairs swimming but not treadmill locomotion.

Figure 17.

Locomotor pattern gradually degrades with removal of proprioceptive feedback. A) Chronic EMG recordings were made during treadmill locomotion and swimming in wild-type and Egr3 mutants that lack functional muscle spindle feedback. B) Bar diagram illustrating the activity of flexor (red) and extensor (blue) muscles during treadmill walking and swimming in wild-type (n = 16 for walking and n = 14 for swimming) and Egr3 mutant (n = 15 for walking and swimming) mice. Each horizontal bar is the average EMG activity in a normalized locomotor cycle (between successive swing or iliopsoas burst onsets for walking and swimming, respectively). GM, gluteus maximum; IP, iliopsoas; St, semitendinosus; TA, tibialis anterior; VL, vastus lateralis. Reproduced and modified from (10).