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. 2022 May 16;13:885113. doi: 10.3389/fphar.2022.885113

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Copyright © 2022 Zhang, Li, Han, Geng, Zhang, Qu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superoxide dismutase (SOD)@zeolite imidazolate framework-8 (ZIF-8) protected cochlear hair cells (HCs) and endocochlear gap junctions from noise-induced hearing loss (NIHL). (A) Representative images of surface preparation of the organ of Corti in the basal–apical cochlear turn from three groups of rats (Control, Vehicle, SOD@ZIF-8). (B) Analysis of HC count in each group. (C,D) Protein expression levels and statistical analysis of Cx26 and Cx30 in the cochleae of various groups. The white asterisk represents the missing outer hair cells (OHCs). Cyan represents 4′6′-diamino-2-phenylindole, and red represents Myosin-VIIa. Data are presented as means ± standard error of mean (SEM) (*p < 0.05, **p < 0.01, and ***p < 0.001, ns: no statistical significance).