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. 2022 May 16;13:885113. doi: 10.3389/fphar.2022.885113

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Copyright © 2022 Zhang, Li, Han, Geng, Zhang, Qu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superoxide dismutase (SOD)@zeolite imidazolate framework-8 (ZIF-8) administration reduced the levels of reactive oxygen species (ROS) and 4-hydroxynonenal (4-HNE) caused by noise. (A–C) Representative images of dihydroethidium staining in the middle–basal cochlear turns from three groups. (D–F) Representative images of 4-HNE staining in the middle–basal cochlear turns from three groups. 4-HNE fluorescence obviously changed in the spiral ganglion neurons (SGNs) (G–I) and organ of Corti (OC) (J–L). (M,N) Protein expression level and statistical analysis of 4-HNE in the cochleae of various groups (StV: Stria Vascularis; OC: Organ of Corti; SGNs: Spiral Ganglion Neurons). Data (N) are presented as means ± standard deviation (SD) (*p < 0.05, **p < 0.01, ns: no statistical significance).