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. 2022 May 16;13:885113. doi: 10.3389/fphar.2022.885113

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Copyright © 2022 Zhang, Li, Han, Geng, Zhang, Qu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superoxide dismutase (SOD)@zeolite imidazolate framework-8 (ZIF-8) administration counteracted inflammation in the cochlea caused by noise exposure. (A,B) Protein expression level and statistical analysis of phosphonuclear factor kappa B (p-NF-κB), interleukin (IL)-6, and IL-1β in the cochleae of various groups. (C) Representative images of IL-1 staining in the middle–basal cochlear turns from three groups (StV: Stria Vascularis; SL: Spiral Ligament; SLB: Spiral Limbus; OC: Organ of Corti; SGNs: Spiral Ganglion Neurons). Data are presented as means ± standard deviation (SD) (**p < 0.01, ***p < 0.001, ns: no statistical significance).