Table 4.
Univariate Analysis of Clinical and Pathological Variables Associated With Local Failure
| Variable | N | LF | Local Failure (%) | |||
|---|---|---|---|---|---|---|
| Years | HR | P | ||||
| 5 | 10 | |||||
| Age at RT | ||||||
| ≤8 Y | 88 | 8 | 94.3 (88.0–97.9) | 91.4 (83.9–96.3) | ||
| >8 (y) | 90 | 4 | 95.6 (89.8–98.6) | 95.6 (89.8–98.6) | 0.5 (0.2–1.6) | 0.26 |
| Histological subtype | ||||||
| Classic/desmoplastic | 152 | 9 | 96 (92.0–98.4) | 94.2 (89.4–97.4) | ||
| Anaplastic | 26 | 3 | 88.5 (72.9–97.2) | 88.5 (72.9–97.2) | 2.1 (0.6–7.7) | 0.27 |
| Sex | ||||||
| Male | 103 | 5 | 97.1 (92.4–99.2) | 95.5 (89.6–98.6) | ||
| Female | 75 | 7 | 91.9 (84.2–96.7) | 90.4 (82.2–95.8) | 2.0 (0.6–6.2) | 0.23 |
| Extent of resectiona | ||||||
| GTR/NTR | 159 | 12 | 94.3 (90.0–97.2) | 92.6 (87.6–96.1) | ||
| STR | 18 | 0 | 100 (–) | 100 (–) | 3.8e−5 (1.8e−5 –8.0e−5) | 0.23 |
| RT duration (days) | ||||||
| ≤45 | 151 | 12 | 94 (89.4–97.1) | 92.1 (86.8–95.9) | ||
| >45 | 27 | 0 | 100 (–) | 100 (–) | 3.4e−5 (1.7e−5–6.7e−05) | 0.12 |
| Risk | ||||||
| Standard | 102 | 7 | 96.1 (91.0–98.7) | 93.5 (87.0–97.4) | ||
| Intermediate/high | 76 | 5 | 93.3 (86.2–97.6) | 93.3 (86.2–97.6) | 1.0 (0.3–3.1) | 1 |
Abbreviations: GTR, gross total resection; HR, hazard ratio; LF, local failure; NTR, near total resection; RT, radiotherapy; STR, subtotal resection.
aThis analysis excludes 1 patient with biopsy only.