Fig. 1.

Investigation functional ncECRs within the AIP genomic locus. A. Panel shows human–rat pair-wise comparison of Human genome (hg19) and Rat genome (rn4). Pink marked lines represent ncECRs, blue marked peaks represent coding exons, green marked peaks represent transposons and simple repeats, salmon marked peaks represent intronic regions, red marked peaks represent intergenic regions, yellow marked peaks represent the untranslated region (UTR: 5′UTR and 3′UTR) of AIP. U1–U6 are conserved regions upstream of AIP, I1–I4 are intragenic conserved regions, while intergenic-5U is the merged as one region by intergenic and 5′UTR sequences. B. Luciferase assay results of ncECRs of the AIP genomic locus. (*P < .05, vs. control.). The experiments were repeated three times with consistent results. The two-tailed Student’s t-tests were used. Bar represents mean ± SD. See online supplementary material for a color version of this figure.