Table 2.

Univariate and Multivariate Cox Regression Analysis of OS

	OS (Univariate)			OS (Multivariate)a			OS (Multivariate)b
	P value	z-score	HR (95%CI)	P value	z-score	HR (95%CI)	P value	z-score	HR (95%CI)
Volume
Pre-ICIs	.47	0.72	1.008 (0.986–1.032)	.84	0.21	1.002 (0.979–1.026)	.41	0.83	1.010 (0.986–1.036)
Post-ICIs	.17	1.38	1.012 (0.995–1.029)	.29	1.06	1.009 (0.992–1.027)	.13	1.53	1.014 (0.996–1.031)
Percentage change	.99	–0.01	1.000 (1.000–1.000)	.74	0.34	1.000 (1.000–1.000)	.51	0.66	1.000 (1.000–1.001)
ADC
Pre-ICIs	.04*	–2.01	0.999 (0.997–1.000)	.08	–1.75	0.999 (0.997–1.000)	.11	–1.60	0.999 (0.997–1.000)
Post-ICIs	.02*	–2.26	0.998 (0.996–1.000)	.03*	–2.15	0.998 (0.996–1.000)	.07	–1.81	0.998 (0.996–1.000)
Percentage change	.24	1.16	1.009 (0.994–1.024)	.31	1.02	1.009 (0.992–1.025)	.23	1.20	1.010 (0.994–1.027)
rADC
Pre-ICIs	.01*	–2.57	0.22 (0.07–0.70)	.04*	–2.11	0.26 (0.07–0.91)	.07	–1.84	0.30 (0.08–1.08)
Post-ICIs	.006**	–2.75	0.22 (0.07–0.64)	.01*	–2.44	0.24 (0.07–0.75)	.045*	–2.00	0.29 (0.08–0.98)
Percentage change	.20	1.30	1.014 (0.993–1.036)	.22	1.23	1.015 (0.992–1.038)	.15	1.43	1.016 (0.994–1.038)

^aControlling for age and sex.

^bControlling for age, sex, and whether a patient underwent surgery after the initiation of ICIs treatment. *P < 0.05, **P < .01.