Table 2.

Multiple linear regression analysis for cognitive function in CSVD-CI group (n = 135).

	β	95%CI	p
General cognitive function
MTA	−0.558	−0.672 to −0.401	<0.001
Education	0.428	0.290 to 0.555	<0.001
Gender	−0.252	−0.387 to −0.104	0.001
Cingulate lobe	−0.163	−0.309 to −0.014	0.032
Episodic memory
MTA	−0.335	−0.512 to −0.159	<0.001
Education	0.184	0.006 to 0.297	0.041
Language
MTA	−0.325	−0.417 to −0.135	<0.001
Education	0.282	0.100 to 0.390	0.001
Gender	−0.196	−0.288 to −0.023	0.020
Information processing speed (inverse)
MTA	0.448	0.339 to 0.702	<0.001
Executive function (inverse)
MTA	0.350	0.180 to 0.582	<0.001
Education	−0.221	−0.413 to −0.079	0.004
PWMH volume	0.207	0.025 to 0.426	0.025
Visuospatial function
Education	0.210	0.032 to 0.383	0.021
MTA	−0.347	−0.660 to −0.196	<0.001
Age	0.263	0.071 to 0.449	0.007

CSVD, cerebral small vessel disease; CSVD-CI, CSVD patients with cognitive impairment; MTA, medial temporal atrophy, the ratio of the ipsilateral lateral subventricular horn to hippocampal volume; PWMH, periventricular white matter hyperintensities; β, standardized coefficients.