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. 2022 Mar 8;10:843687. doi: 10.3389/fcell.2022.843687

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Copyright © 2022 van Opbergen, Sall, Petzold, Dancel-Manning, Delmar and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Connexin43 hemiplaques in adult hearts of Plakophilin-2 conditional knock out mice (PKP2cKO). (A) Representative examples of gap junction plaques in control and PKP2cKO hearts, emphasizing in the right panel Connexin43 (Cx43) hemiplaques in a PKP2cKO ventricular sample. Arrowheads point out Cx43 hemiplaques. Scale bar: 0.5 µm. (B) Quantification of the percentage of gap junction plaques containing Cx43 hemiplaques in control and PKP2cKO hearts, left ventricular (LV) and right ventricular (RV) samples separately. Data presented as percentage of total pool. Control LV; n = 27, PKP2cKO LV; n = 21, Control RV; n = 30, PKP2cKO RV; n = 30. (C) Representative examples of 3D Cx43 Immuno-Electron Microscopy images of a PKP2cKO heart presenting a Cx43 hemiplaque. The various frames (1–3) correspond to different section levels of the same samples. Arrowheads point out Cx43 hemiplaques. Scale bar: 0.5 µm. (D) Quantification of the total length of Connexin43 hemiplaques in control and PKP2cKO hearts, LV and RV samples separately. Data presented as total length of total pool. Control LV; n = 3, PKP2cKO LV; n = 7, Control RV; n = 3, PKP2cKO RV; n = 18. (E) Quantification length of Connexin43 hemiplaques in control and PKP2cKO hearts, corrected for the total length of the gap junction plaque. LV and RV samples are quantified separately. Data presented as percentage of total length per group. Control LV; n = 27, PKP2cKO LV; n = 21, Control RV; n = 30, PKP2cKO RV; n = 30.