FIGURE 2.

Comparison of mechanism of action of OSH, pufferfish‐inspired hydrogel, light‐degradable hydrogel, and ED. Comparison of mechanism of action of OSH (A), the pufferfish‐inspired hydrogel (B), a light‐degradable hydrogel device (C), and ED (D). Note, both endoscopic and ingestible light sources can be used to trigger degradation of the hydrogel‐release mechanism of the light‐degradable hydrogel device. Volume is dependent on the fluid absorption capacity of the hydrogel. Elasticity is the ability of a material to maintain its normal shape after being compressed. Time to hydrate is the amount of time required for hydration and maximizing elasticity. Degradation is the rate of dissociation of the hydrogel and release of fluid in the colon. ED, Epitomee device; GI, gastrointestinal; OSH, oral superabsorbent hydrogel