Fig. 6. Differential open chromatin at genes located within GWAS loci for COVID-19 hospitalization.

Two of the five GWAS loci for severe COVID-19 with respiratory failure contain multiple DACs in monocytes from hospitalized patients with COVID-19 (33). The y axis indicates the evidence for association of single-nucleotide polymorphisms (SNPs) (dots in the top panels) with severe COVID-19 as negative log₁₀ P value. The x axis indicates the chromosomal location of SNPs with colocalizing genes shown below. A zoom-in at the four regions with DAC for the deceased versus alive contrast is shown in the lower part of the figure. Box plots with normalized quantification of pileup fragments in peaks at promoter regions for deceased and alive are shown as log₂ CPM for patient groups at admission and follow-up.