Table 3. Sensitivity analysis of the diagnostic accuracy of canine detection, as compared to several references.
| Reference standard | Total, n | Positive samples, n | Sensitivity (95% CI*) | Specificity (95% CI) |
|---|---|---|---|---|
| NPS RT-PCR ≥ 2 targets | 335 | 108 | 97% (92 to 99) | 91% (86 to 94) |
| Symptoms | 143 | 77 | 96% (89 to 99) | 82% (70 to 90) |
| No symptoms | 192 | 31 | 100% (89 to 100) | 94% (90 to 97) |
| NPS RT-PCR ≥ 1 target and Ct value < 32 | 335 | 107 | 97% (92 to 99) | 90% (86 to 94) |
| Symptoms | 143 | 76 | 96% (89 to 99) | 81% (69 to 89) |
| No symptoms | 192 | 31 | 100% (89 to 100) | 94% (90 to 97) |
| Saliva RT-PCR ≥ 1 target | 320 | 80 | 90% (81 to 96) | 81% (75 to 86) |
| Symptoms | 136 | 53 | 96% (87 to 100) | 65% (54 to 75) |
| No symptoms | 184 | 27 | 78% (58 to 91) | 89% (83 to 94) |
| NPS RT-PCR ≥ 1 target or | 327 | 116 | 92% (86 to 96) | 91% (87 to 95) |
| Saliva RT-PCR ≥ 1 target | ||||
| Symptoms | 142 | 79 | 96% (89 to 99) | 84% (73 to 92) |
| No symptoms | 185 | 37 | 84% (68 to 94) | 95% (90 to 98) |
| NPS RT-PCR ≥ 1 target or | 327 | 112 | 95% (89 to 98) | 91% (87 to 95) |
| Saliva RT-PCR ≥ 1 target and Ct value < 32 | ||||
| Symptoms | 142 | 78 | 96% (89 to 99) | 83% (71 to 91) |
| No symptoms | 185 | 34 | 91% (76 to 98) | 95% (90 to 98) |
| NPS antigen | 234 | 80 | 95% (88 to 99) | 83% (76 to 89) |
| Symptoms | 123 | 60 | 97% (88 to 100) | 71% (59 to 82) |
| No symptoms | 111 | 20 | 90% (68 to 99) | 91% (83 to 96) |
*95% CI: 95% Confidence Interval.