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BMPR II mediates the integrity of the BBB induced by RGMa. (A, B) Immunofluorescence showed BMP2 and BMPR II were expressed in HBMECs. Scale bar: 50 µm. (C–E) Both BMP2 and BMPR II expression levels were significantly increased after overexpressing RGMa (n = 3, * p < 0.05, t-test). (F–I) On the basis of overexpressing RGMa, specifically silencing BMPR II significantly augments ZO-1 and claudin-5 expression (n = 3, * p < 0.05, t-test). **p < 0.01.
