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. 2022 May 25;2022:9444227. doi: 10.1155/2022/9444227

Figure 3.

Figure 3

NLRP3/caspase-1 inhibitor downregulated inflammasome activation and downstream factors. (a, b) Protein expression of NLRP3 (117 KD) and IL-1β (35 KD) in lung homogenates was detected by western blot, and densitometric analysis was performed. (c) The concentration of IL-1β and IL-18 in BALF was quantified by ELISA. (d) mRNA expression of Nlrp3, caspase-1, IL-1β, and IL-18 in lung homogenates was detected by real-time PCR. Data are expressed as mean ± SEM. n = 6. Compared to the control group, ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001; compared to the neutrophilic asthma group, #p < 0.05, ##p < 0.01, and ###p < 0.001. NLRP3: nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3; BALF: bronchoalveolar lavage fluid; ELISA: enzyme-linked immunosorbent assay; PCR: polymerase chain reaction.