Table 1.
AN69 | AN69ST | PMMA | oXiris | PMX-HP | CytoSorb | |
---|---|---|---|---|---|---|
Characteristic | Nonselective | Nonselective | Nonselective | Semiselective | Selective | Nonselective |
Year of development | Flat sheet in 1972, hollow fiber in 1980 | Flat sheet in 1998, hollow fiber in 2000 | — | 2009 | 1994 | 2011 |
Adsorption material | A copolymer of acrylonitrile and sodium methallyl sulfonate | Treated with cationic polymer on the basis of AN69 | Polymethyl methacrylate | Polymerized by acrylonitrile and methallyl sulfonate | Polymyxin B bonded to the surface of polystyrene derivative fibers | Divinylbenzene copolymer beads with biocompatible |
Cytokines removal | Yes Up to 35 kDa |
Yes Up to 35 kDa |
Yes Up to 65 kDa |
Yes Up to 35 kDa |
No | Yes Up to 60 kDa |
Endotoxin removal | No | No | Yes | Yes | Yes | No |
Main application fields | Dialysis, sepsis | Dialysis, sepsis | Dialysis (PMMA-CVVH) | Dialysis, sepsis | Sepsis, pulmonary diseases | Sepsis, septic shock, AKI, COVID-19, ECMO, CPB |