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. 2022 May 25;606(7912):165–171. doi: 10.1038/s41586-022-04752-8

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© The Author(s) 2022, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 12 — a, Representative flow cytometric profiles of Epcam⁺CD45^– TECs from wild-type (left panel) and Foxn1:Fgf7 transgenic (right panel) mice at either 4-weeks (P28) or 1-year (1 yr) of age (top and bottom rows respectively); the percentages of individual TEC subpopulations are indicated in the respective gates. b–d, Numerical analysis of TEC subpopulations based on flow cytometry. For b-d, Wt P28, n = 11; Fgf7 tg P28, n = 12; Wt 1 yr, n = 10; Fgf7 tg 1 yr, n = 18. Data are shown as mean±s.e.m. e–h, Flow cytometric analyses of CD45⁺ thymocyte populations; DN, CD4^–CD8^–; DP, CD4⁺CD8⁺; CD4SP, CD4⁺CD8^–; CD8SP, CD4^–CD8⁺. For e-h, Wt P28, n = 11; Fgf7 tg P28, n = 12; Wt 1 yr, n = 10; Fgf7 tg 1 yr, n = 18. Data are shown as mean±s.e.m. t-test; two-sided; P values are indicated. i, j, UMAP representation of progenitor and mature TEC populations in Foxn1:Fgf7 transgenic mice at (i) P28 and (j) 1 year of age.

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