Fig. 3. Autocrine Fgf stimulation results in sustained thymic hyperplasia.
a–c, Quantitative assessment of thymopoiesis in wild-type (WT) and Foxn1-Fgf7 transgenic (Tg) mice at 4 weeks and 1 year of age. a, WT P28, n = 18;Tg P28, n = 19; WT 1 yr, n = 10;Tg 1 yr, n = 18. b, WT P28, n = 19; Tg P28, n = 21; WT 1 yr, n = 10; Tg 1 yr, n = 18. c, WT P28, n = 18; Tg P28, n = 19; WT 1 yr, n = 10; Tg 1 yr, n = 18. Data are shown as the mean ± s.d. P values are indicated from two-sided t tests. d, Representative photographs of thymi from the mice analysed in a; scale bar, 10 mm. e–g, Transcriptome features of TEC clusters expressed as ratios of progenitor and mature TEC gene set transcript counts. Assignment of clusters to the four main populations in the coordinate system is indicated in e; the sizes of dots correspond to the relative fraction in the TEC population. h, Summary of dynamic changes in the composition of the TEC compartment. i, j, P values (–log10) of barcode frequencies indicating co-occurrence of individual barcodes in progenitor and mature TEC fractions (as defined in Fig. 1c–f) at two time points. P values were calculated as described in the Methods and corrected for multiple testing by the Benjamini–Hochberg method. The red numbers correspond to clones discussed in the text. k, Schematic indicating the divergent developmental trajectories of embryonic and postnatal epithelial progenitors. Line thickness corresponds to lineage bias; the dashed line indicates the presumptive lineage relationship of the two progenitor populations.