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. 2022 May 25;606(7912):165–171. doi: 10.1038/s41586-022-04752-8

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© The Author(s) 2022, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, b, Five transcriptional trajectories each define the gene sets characterizing embryonic (a) and postnatal (b) progenitors. Gene lists are given in Supplementary Tables 1 and 2. The P28 time point is used as the reference point for expression levels. c, d, Expression values of individual genes in the sets characterizing embryonic (c) and postnatal (d) progenitors. Most genes exhibit low expression values. e, Pathway analysis of unique gene sets (Supplementary Tables 1–4) characterizing early and postnatal progenitors and mature cTECs and mTECs. The three most enriched biological processes each as defined by the database for annotation, visualization and integrated discovery (DAVID) annotation tool^75,76 are shown; the genes driving the enrichment for the GO categories are listed in Supplementary Table 6. Both progenitor populations express a number of heat shock protein genes, which are not considered here

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