Extended Data Fig. 5. Comparative analysis of scRNA-seq data.

a–d, Projection of aggregated read-counts for gene sets defining early and postnatal progenitors and mature cTEC and mTEC (Supplementary Tables 1–4) onto the 9 major TEC subsets defined by Baran-Gale et al. (1). Whereas the early progenitor signature cannot be unequivocally assigned, the postnatal progenitor signature maps to the intertypical TEC subset; the cTEC and mTEC signatures match the description of Baran-Gale et al.¹. e, Analysis of scRNA-seq data of Baran-Gale et al.¹ visualized using UMAP. Their 9 different TEC subtypes are distinguished by different colours, matching the code in a-d. f, Projection of aggregated read-counts for the early progenitor gene set onto the UMAP, indicating partial overlap with cells referred to as mature and perinatal cTECs. g, Projection of aggregated read-counts for the postnatal progenitor gene set onto the UMAP indicating good correspondence with the majority of intertypical TECs.