Extended Data Fig. 10. Some Mtb clinical strains have loss-of-function mmpL5 mutations that render them hypersensitive to bedaquiline and clofazimine.

Dose-response curves (mean ± SEM, n = 3 biological replicates) for a reference set of Mtb clinical strains⁶⁶. b, Dose-response curves (mean ± SEM, n = 3 biological replicates) for the listed Mtb strains. The L1.1 strain (mmpL5 Tyr300Stop) in panel a was transformed with an integrating plasmid expressing either an empty vector (EV) or the mmpS5 + mmpL5 operon driven by the endogenous (pNative) or hsp60 promoter.