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. 2022 May 30;7(6):766–779. doi: 10.1038/s41564-022-01130-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Structure of LZD, CLR and STR bound to the Thermus thermophilus ribosome. PDB codes: 3DLL, 1J5A, 1FJG, 4V5C. b, Heatmap depicting chemical-genetic interactions as in Fig. 2a. c, Chemical-genetic hit genes from Fig. 3b are involved in diverse cellular pathways. Genes whose inhibition decreased or increased fitness in the indicated drug are listed in blue or red, respectively. d, Dose-response curves (mean ± s.e.m., n = 3 biological replicates) for the indicated CRISPRi strains in H37Rv or rplC-Cys154Arg linezolid-resistant H37Rv (LZD^R).

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