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. 2022 May 30;7(6):766–779. doi: 10.1038/s41564-022-01130-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a-i, Normalized growth (mean ± SEM, n = 3 biological replicates) of the Mtb CRISPRi library in the drug screens. Samples harvested for sgRNA deep sequencing are marked as “High”, “Med”, and “Low”, denoting the three descending doses of partially inhibitory drug concentrations analyzed in these screens. **: 10-day sample was lost for the 221 nM (“Med”) streptomycin screen. One biological replicate was lost for the 1,804 nM (“Med”) EMB 1-day screen; to obtain three replicate samples, one biological replicate was prepared in technical duplicate.