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. 2022 May 30;7(6):766–779. doi: 10.1038/s41564-022-01130-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Histogram depicting the number of unique chemical-genetic interactions for enriching and depleting hits. Hit genes were defined as the union of 1 and 5-day CRISPRi library pre-depletion results. b-j, Bar graphs showing the number of hit genes identified across all drugs. Gene essentiality calls were defined by CRISPRi¹⁵. D1, D5, and D10 indicate the number of days the CRISPRi library was treated with ATc prior to drug exposure; D1 + 5 = hit genes defined as the union of 1 and 5-day CRISPRi library pre-depletion results; D1 + 5 + 10: hit genes defined as the union of 1, 5 and 10 day CRISPRi library pre-depletion results. The 10-day sample was lost for the “Med” streptomycin screen and thus the D10 containing results for “STR–Med” are labelled “missing”. BDQ = bedaquiline; CLR = clarithromycin; EMB = ethambutol; INH = isoniazid; LVX = levofloxacin; LZD = linezolid; RIF = rifampicin, STR = streptomycin; VAN = vancomycin.