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. 2022 May 4;606(7912):153–159. doi: 10.1038/s41586-022-04686-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, (left) Overlap between P4 NE-open ATAC peaks and gonadally intact adult male-biased ATAC peaks. (right) Overlap between P4 NE-close ATAC peaks and gonadally intact adult female-biased ATAC peaks. b, Dotplot of BETA enrichment p-values for P4 NE-open ATAC peaks (top) and NE-close ATAC peaks (bottom) at adult BNST snRNA-seq sex DEGs relative to a background of non-differential, expressed genes (see also Fig. 2h). c, Histogram of mean distance between P4 NE-open peaks and nearest gonadally intact adult male-biased ATAC peak (red line) vs. nearest chromosome-matched, non-differential adult ATAC peak (n = 1000 permutations) (blue histogram). Mean distance between P4 NE-open peaks and adult male-biased peaks is significantly smaller than the expected distribution (Permutation test, p = 0.007). d, Example adult male-biased DEGs (Prlr, Cckar, Pdzrn4, Tiparp) with neighboring P4 NE-open (highlighted in yellow) and adult male-biased ATAC peaks (highlighted in purple).