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. 2022 May 16;7(6):780–795. doi: 10.1038/s41564-022-01121-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Heatmap showing the overall pattern of correlation between significant and stability-selected host genes (rows) and gut microbial taxa (columns) identified by the lasso model in CRC, IBD and IBS (FDR < 0.1). b, Host pathways enriched among genes that are correlated with specific gut microbes in CRC (purple), IBD (green) and IBS (yellow) (FDR < 0.1). c–e, Networks showing specific gut microbes correlated with specific host genes enriched for disease-specific host pathways in CRC (c), IBD (d) and IBS (e). Triangular nodes represent gut microbes, circular nodes represent host genes and pathways. Edge colour represents positive (blue) or negative (red) association, and edge width represents strength of association (Spearman rho). Grey edges represent host gene–pathway associations.