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. 2022 Mar 17;32(6):543–554. doi: 10.1038/s41422-022-00639-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Percentage of the top 50 most frequent clones of CD3β in tumors from Ctr mRNA or VEGF-C mRNA groups on day 22 after inoculation (n = 3). b Comparison of CDR3β clonotype numbers in tumors from Ctr mRNA or VEGF-C mRNA groups on day 22 after inoculation (n = 3). c Quantification of CD8⁺ T cells expressing multiple cytokines in tumors from Ctr mRNA or VEGF-C mRNA groups on day 22 after inoculation (n = 6). d Illustration of the role of MLVs in brain tumors with RT. The MLV-CLN network mediates the RT-modulated anti-tumor immunity and contributes to RT efficacy. Data are presented as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001; Student’s t-test (b, c). Data are from at least two (c) independent experiments.