Table 1.

Lipid based nanoparticles in clinical trials.

Composition	Chemotherapy	Immunotherapy	Type of Cancer	Mode of Operations	References
Liposomes
PEGylated liposomes	Doxorubicin	Alendronate	Breast cancer	i.v.	[46]
Charge-reversal cell penetrating peptide-modified liposomes	Paclitaxel	PD-L1 antibody	Melanoma	i.v.	[47]
pH-responsive liposomes	Mitoxantrone	Indoximod	Breast cancer and renal cancer	i.v.	[48]
Enzyme/pH dual-sensitive micelle-liposomes	Paclitaxel	HY19991	Metastatic breast cancer	i.v.	[49]
Hybrid lipid-based nanoparticles
Thermo-sensitive exosome-liposome hybrid nanoparticles	Docetaxel	GM-CSF	Metastatic peritoneal carcinoma	i.v.	[50]
Lipid-coated calcium nanoparticles	Zoledronate	Zoledronate	Lung cancer	i.v.	[51]
Liposome-coated mesoporous silica nanoparticles	All-trans retinoic acid + doxorubicin	IL-2	Melanoma	i.v.	[52]
Nano discs
HDL-Nano disc	Doxorubicin	αPD-1	Colorectal cancer	i.v.	[53]
	Docetaxel Colon	Cholesterol modified CpG	carcinomas	Intra-tumoral	[54]