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. 2021 Sep 3;43(6):1360–1371. doi: 10.1038/s41401-021-00759-5

Fig. 2. Metformin improves locomotor functional recovery after SCI.

Fig. 2

a The BBB score in the Sham, SCI and SCI + Met group (n = 8). b Angle of incline in different groups (n = 8). c Footprint analysis results of each group. Both the forepaws and hindpaws of rats were dipped in red and blue dye (n = 8). d H&E staining result for the lengthwise section of spinal cord in each group. Scale bar = 1 mm. e Quantification analysis of the lesion cavity area in H&E staining of spinal cord (n = 5). *P < 0.05, **P < 0.01 vs. SCI group. SCI spinal cord injury, Met metformin, BBB, Basso, Beattie, and Bresnahan, H&E hematoxylin and eosin.