Skip to main content
. 2022 Feb 14;32(6):530–542. doi: 10.1038/s41422-022-00627-9

Fig. 4. T cells from tumor-enriched clusters recognize neoantigens.

Fig. 4

a FACS plots showing the IFNγ expression in TCR-T cells stimulated with LCLs expressing tandem minigenes of tumor mutations and control. b, c Bar plots showing the fold change of IFNγ expression in each TCR-T cell line stimulated with LCLs expressing tandem minigenes compared to the stimulation with control LCLs (right panel); The top five tumor TCRs in each group of P4 (b) and P5 (c) were presented. d, e Growth of P4 (d) and P5 (e) PDX tumors treated with TCR-T cells expressing top three TCRs indicated in groups in (b, c); Non-tranduced T cells were used as control. Representative of two independent experiments (n = 5 mice/group, each value represents means ± SEM, **P < 0.01 by two-sided t-test).